Peroxidase-mimicking nanozymes that can generate toxic hydroxyl radicals (
.OH) hold great promise as antibacterial alternatives. However, most of them display optimal performance under strongly acidic conditions (pH 3–4), and are thus not feasible for many medical uses, including burn infections with a wound pH close to neutral. Herein, we report a copper-based nanozyme (CuCo
2S
4) that exhibits intrinsic peroxidase-like activity and can convert H
2O
2 into
.OH at neutral pH. In particular, bimetallic CuCo
2S
4 nanoparticles (NPs) exhibited enhanced peroxidase-like activity and antibacterial capacity, superior to that of the corresponding monometallic CuS and CoS NPs. The CuCo
2S
4 nanozymes possessed excellent ability to kill various bacteria, including methicillin-resistant
Staphylococcus aureus (MRSA). Furthermore, this CuCo
2S
4 nanozymes could effectively disrupt MRSA biofilms in vitro and accelerate MRSA-infected burn healing in vivo. This work provides a new peroxidase mimic to combat bacteria in neutral pH milieu and this CuCo
2S
4 nanozyme could be a promising antibacterial agent for the treatment of burn infections.
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